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It led to him finally mouthing those words “I need help” after having wanted help for so long. In the year 1990, Elton began realizing just how bad his life had become, and the cause of it was his consistent use of drugs. It was like he was flying blind from day to day. Elton John stated, “It was like something had been switched back on inside me, like a pilot light that had gone out.” This pilot light “that had gone out” was Elton John as if his life had been on autopilot, with him not being in control of his life anymore. Dick James Music company vinyl | Introduced Elton John to cocaine | J| Courtesy of FlickrĪ week before Elton went into rehab in 1990, Elton said the words, “I need help.” 1 When Elton mouthed those words, he suddenly felt different about himself, realizing that a light had been switched back on. Ladies and gentleman, here is Elton John. ![]() In one moment, Elton John came to a realization that he was in bad shape, and that he really needed to make a big change in his life. He had to learn the hard way how impactful drugs could be in his life. Would you try drugs to make yourself more outgoing? Would you ever have thought that famous artists go through depression? Have you ever wondered what it’s like to get hooked on drugs and have your life turned upside down? Elton John had those things happen to him at the beginning of his career. SC 3300 – Special Topics: Public Health.HS 1302 – United States History since 1877.HS 1301 – United States History to 1877.3 Post-Classical History (600 CE-1492 CE).6 Contemporary Latin America (2000-2030).1 Pre-Columbian Latin America (to 1492).4 Late Middle Ages-Renaissance-Reformation Europe (1300-1648).6 Great Depression and WWII (1929-1945).5 Emergence of Modern America (1877-1929).4 Civil War and Reconstruction (1850-1877).2 Revolution and Early Republic (1754-1801). ![]()
![]() Furthermore, we have identified compounds with activity against DLK and LZK that potently promote survival of mouse and human RGCs, including the FDA-approved multi-kinase inhibitor sunitinib. We previously developed a primary cell-based method to perform high-throughput, functional genomic screening and we and others identified dual leucine zipper kinase (DLK MAP3K12) and leucine zipper kinase (LZK MAP3K13) as key mediators of RGC cell death in response in axonal injury. However, maintaining lower pressure can be challenging in some patients, and in others, even if significant pressure lowering is achieved, RGC loss continues. All of the current standard-of-care treatments for glaucoma are aimed at lowering intraocular pressure (IOP). Glaucoma is a neurodegenerative disease that causes irreversible vision loss due to the death of retinal ganglion cells (RGCs). Due to the rapid increase in the aging population, the number is expected to rise to 111 million by 2040. Glaucoma is the leading cause of irreversible blindness, impacting 80 million people worldwide. For a chronic disease such as glaucoma, a formulation that provides sustained therapeutic effects to complement IOP lowering therapies could provide improved disease management and promote patient quality of life. Importantly, therapeutically relevant retina drug concentrations were achieved with subconjunctival injection of SPC microcrystals in pigs. Furthermore, subconjunctival injection of SPC microcrystals also led to therapeutic effects in a rat model of corneal neovascularization. A single subconjunctival injection of sunitinib-pamoate complex (SPC) microcrystals provided 20 weeks of sustained retina drug levels, leading to neuroprotection in a rat model of optic nerve injury. Here, we describe an ion complexation approach for formulating microcrystals containing ~50% loading of a protein kinase inhibitor, sunitinib, to enhance survival of RGCs with subconjunctival injection. A complementary strategy to IOP reduction is the use of neuroprotective agents that interrupt the process of cell death by mechanisms independent of IOP. ![]() However, degeneration of retinal ganglion cells (RGCs) may continue to progress despite extensive lowering of IOP. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. Glaucoma is the leading cause of irreversible blindness worldwide. Version history available = Complete changelog on our site. ![]() Old versions available = Download old versions of the program. Portable version available = Download the portable version and you can just extract the files and run the program without installation. This program now comes with Windows Media Center, which is a must-have for anyone who loves watching DVDs. It may not contain the latest versions.ĭownload old versions = Free downloads of previous versions of the program.ĭownload 64-bit version = If you have a 64bit operating system you can download this version.ĭownload portable version = Portable/Standalone version meaning that no installation is required, just extract the files to a folder and run directly. If you have an older computer that still runs and works well but lacks the space needed for Windows 8 or Windows 10, you can download Windows 7 Home Premium to keep your computer operating at a higher level. Visit developers site = A link to the software developer site.ĭownload (mirror link) = A mirror link to the software download. Subler alternatives are mainly Video Converters but may. Be careful when you install the software and disable addons that you don't want! Other interesting Windows alternatives to Subler are FFmpeg, Avidemux, MKVToolnix and XMedia Recode. Ad-Supported = The software is bundled with advertising. command file in a text editor to see what it is doing. No installation is required.ĭownload beta = It could be a Beta, RC(Release Candidate) or an Alpha / Nightly / Unstable version of the software.ĭownload 15MB = A direct link to the software download. download SublerCLI from the same place as Subler put it in /usr/local/bin the attached file 'mand' is a shell script that will take a folder of mp4 and srt movies and combine them (if they have the same name) open the. Portable version = A portable/standalone version is available. Free Trial version available for download and testing with usually a time limit or limited functions. Trialware = Also called shareware or demo. It may be disabled when installing or after installation. Free software Ads = Free Download software and open source code but supported by advertising, usually with a included browser toolbar. Freeware Ads = Download Free software but supported by advertising, usually with a included browser toolbar. Free software Trialware = Download Free software and also open source code but some parts are trial/shareware. ![]() Free software = Download Free software and also open source code also known as FOSS (Free and Open Source Software). Freeware Trialware = Download Free software but some parts are trial/shareware. RECENTLY UPDATED = The software has been updated the last 31 days. NO LONGER DEVELOPED = The software hasn't been updated in over 5 years. Type and download NO MORE UPDATES? = The software hasn't been updated in over 2 years. ![]() Version number / Beta version number / Update version number and when it whas released. Explanation: NEW SOFTWARE= New tool since your last visit NEW VERSION= New version since your last visit NEW REVIEW= New review since your last visit NEW VERSION= New version Latest version ![]() ![]() ![]() Digital signaturesĪpple and many other motherboard manufacturers eventually went one step further, and organised things so that the firmware chip could only be updated by code already contained in the firmware.įor additional security (and control), firmware updates would only go ahead if the new firmware version was digitally signed by the motherboard vendor. In other words, only by using special hardware configuration settings could the firmware be updated, which prevented accidental overwrites. (They’re still commonly called “Boot ROMs,” but they are no longer truly read-only.) To fix bugs, you had to extract the chip and replace it with a new one – a troublesome task on a single computer, let alone in an office full of them.įor convenience, therefore, Boot ROMs were ultimately replaced by Flash chips that were usually write-protected, but could be rewritten under controlled conditions. So, Boot ROMs couldn’t be infected with malicious code, which was very handy but they couldn’t be updated or patched, either. In the early days, computer firmware was stored in a special Boot ROM chip – a read-only memory device that was programmed in the factory, plugged into your computer, and remained forever unmodified and unmodifiable. To explain: the firmware is a sort-of hardware-level operating system, stored in a special chip on the motherboard, that prepares your computer for running a regular operating system such as OS X or Windows. The sequel builds on work reported at the start of 2015 that used security holes in the firmware on your Mac to inject malicious code into the very earliest part of the boot process, where it can run long before OS X itself. – Thunderstrike courtesy of Shutterstock –Īnd like your favourite movie sequel, it’s called Thunderstrike 2. ![]() GOM does have excellent playlist support. If you enjoy watching movies from the couch, reaching for the mouse to choose another video seems dreadful. You can do that by right-clicking anywhere in the playback window and selecting Subtitles. ![]() And when you are done, just hit save and as long as you have the Auto Font Resizing option enabled, every new subtitle will behave in the same way. You can also increase or decrease font size. If you think the default white color is too distracting, you can change that to something a bit cooler, like lime green. You can change every aspect of how the subtitle is displayed on the screen by going into Preferences -> Subtitles. If you are not satisfied with the default looks of the subtitles, I have good news. From here you can change the default shortcut for any action or assign new ones. GOM has a sizeable collection of those to start with. You can do the same for keyboard shortcuts as well from Keyboard. There are many options available but if you are looking for some inspiration, check out the image below. To start off, you can assign different actions to Mouse Wheel Scroll Up/Down, Center Button Click, Left Button Double Click etc. The default shortcuts from GOM are pretty minimal but you can tinker with it all you want. ![]() Here you can assign specific shortcuts to any major playback activity. Press F5 to go into Preferences, click the General option in the left sidebar and then choose Mouse or Keyboard from the menubar. Assign ergonomic Mouse and Keyboard Shortcuts In this article we talk about how to make GOM better for you. It has more features, has just as good codec support and it’s actually faster than VLC.įind out more about why you should go for it in our review here. You can follow above instructions to install GOM Remote - Remote Controller for PC with any of the Android emulators available. You can either install the app from Google PlayStore inside the emulator or download GOM Remote - Remote Controller APK file and open the APK file with the emulator or drag the file into the emulator window to install GOM Remote - Remote Controller for PC.Associate or set up your Google account with the emulator.Open the emulator software from the start menu or desktop shortcut in your PC.How to Download and Install GOM Remote - Remote Controller for PC or MAC: Select an Android emulator: There are many free and paid Android emulators available for PC and MAC, few of the popular ones are Bluestacks, Andy OS, Nox, MeMu and there are more you can find from Google.Ĭompatibility: Before downloading them take a look at the minimum system requirements to install the emulator on your PC.įor example, BlueStacks requires OS: Windows 10, Windows 8.1, Windows 8, Windows 7, Windows Vista SP2, Windows XP SP3 (32-bit only), Mac OS Sierra(10.12), High Sierra (10.13) and Mojave(10.14), 2-4GB of RAM, 4GB of disk space for storing Android apps/games, updated graphics drivers.įinally, download and install the emulator which will work well with your PC's hardware/software. Let's find out the prerequisites to install GOM Remote - Remote Controller on Windows PC or MAC computer without much delay. GOM & Company published GOM Remote - Remote Controller for Android operating system mobile devices, but it is possible to download and install GOM Remote - Remote Controller for PC or Computer with operating systems such as Windows 7, 8, 8.1, 10 and Mac. Download GOM Remote - Remote Controller PC for free at AppsPlayground. ![]() Clingy Jealous Girl: Heather for Silas.Broken Bridge: Landslides have closed off part of the world.Brilliant but Lazy: JJ's pretty smart, if not really, really dumb.ItMakesSenseInContext.Brain Bleach: In response to Art wearing a ballroom gown: "There are some things you just can't unsee.".Wandering Willows includes examples of the following tropes: And if you think it sounds strange from just our description alone, you don't know the half of it. Wandering Willows is a 2009 simulation/RPG released by Play First. Whether the people of the island will be more of a help than a hinderance remains to be seen! So you set off on your quest to fix your balloon. ![]() The villagers agree to help you, if a bit skeptically. But you're a bit more Hot-Blooded than that, and you're determined to find your way home. They've all decided they're perfectly OK with living on the island it isn't as if it isn't hospitable, after all. And they all have an unusual backstory: All of them came to the island in some type of crash or other disaster. The good news is, the island is inhabited! In fact, it has houses and shops-it's more of a tiny wayward village than anything else. The bad news is, your hot air balloon is completely wrecked. You steer yourself to a crash landing on a nearby island. But a storm picks up, and while you navigate it bravely, a wayward seagull collides with your balloon. An Adventurer Is You, and you and your trusty hot air balloon are soaring high above the waves. It's a beautiful day above the big blue sea. Just before finishing, turn down the heat and add several cups of Lost. ![]() Dice up the Animal Crossing and add it to the pot. Start with a big, bubbling pot of Harvest Moon. ![]() There you will see an install button click on it. Click on Download File of Farming Simulator 19 Mod APK Game. We'll help you find the best deal for the right gear to run the game. How to Install Farming Simulator 19 APK Once the download process is complete, follow the given steps for the installation process: Go to the browser and go to Settings menu > Security settings. Filter for Farming Simulator 19 graphics card comparison and CPU compare. Looking for an upgrade? Try our easy to use Farming Simulator 19 set up guides to find the best, cheapest cards. But these specs should still be fine for running the game in 1080p with a decent FPS.Ĭheck here, if you are looking for news on the latest game and Farming Simulator 22 system requirements.įarming Simulator 19 will run on PC system with 64-bit Windows 7, Windows 8, Windows 10 and upwards. The developers do not give any recommended requirements, just minimum. How To Download 19 Farming Game Without Verification Skip. The cheapest graphics card you can play it on is an AMD Radeon HD 7770. Farming Simulator 19 Mobile Download Play FS 19 For Android APK IOS. Step 1 Search Game Name Step 2 click download now Step 3 click on i am not robot for download iso file Step 4 click any 1 offer like game or app Step 5. ![]() An Intel Core i3-2100T CPU is required at a minimum to run Farming Simulator 19. The minimum memory requirement for Farming Simulator 19 is 4 GB of RAM installed in your computer. In terms of game file size, you will need at least 20 GB of free disk space available. The Farming Simulator 19 system requirements are fairly undemanding. ![]() The blanket also includes a leg pouch for an especially snug fit during the baby’s first weeks to reduce colic. When the baby is swaddled the beads provide gentle pressure that mimics your touch and provides relief. If you’d like to read the benefits of swaddling, you can do so here. It uses the benefits of swaddling and touch with its built in small pockets of poly-beads that are strategically placed around the blanket. The Zen Swaddle Blanket is a great solution for parents who swaddle their babies for comfort. Easier to use than traditional swaddle blankets.He not only sleeps longer but can fall back asleep more easily when he becomes startled with noise or movement. The Zen Swaddle is soft, lightweight, easy-to-use and keeps my baby sleeping longer during nap time and at night time. It has become our go-to baby gear that’s used all the time. I’ve been using Nested Bean’s Zen Swaddle for about two weeks now and I’ve fallen in love with this product. The only downside to it was that traditional swaddling blankets would come loose, sometimes covering their faces and simply keeping them from staying asleep throughout the night. When the baby fusses or cries without being able to sleep and stay asleep, it’s because his hands come loose and he scares himself with sudden movements. We are very familiar with swaddling and have swaddled both of our daughters with success. My goal these days is to keep him asleep for at least 3-4 hours at a time and to help him fall asleep more easily without fussing as much. Now that the initial high of motherhood has passed (don’t get me wrong, I love this little boy so much that my heart hurts), I’m trying to settle into a routine with my baby boy. I even reached a few postpartum milestones such as wearing jeans (yay!) and getting fresh after-baby hair color (double yay!). I’m trying to be more flexible and listen to my mind and body and so far it has worked wonders in keeping my spirits up despite the sleep deprivation. ![]() I got an OK from the doctor to begin light exercise, which I plan to do from next week or so. ![]() Baby D is almost two months old now, where did the time go? If you follow me on Instagram, you would know that I’ve been slowly transitioning back to normal pre-pregnancy life. ![]() Connect that HDMI adapter to the video output port on the Mac.With everything ready, it’s time to hook everything up and get the connection going, here’s how to connect the Mac to a TV with HDMI: The Mini-DisplayPort to HDMI adapter that connects to the Mac will look something like this: The location of the video output port varies per Mac model, but it’s usually on the right-side of the MacBook Air, the left side on the MacBook Pro, and it’s always on the back of the iMac and Mac Mini. If the MacBook, MacBook Air, MacBook Pro doesn’t have an HDMI port, and you have never connected anything to a Mini-Display Port or Thunderbolt Port, you’re looking for this port which requires the adapter: If the MacBook Pro has an HDMI port, you can just connect the HDMI cable to the port, this is what it looks like: Connect the Mac to the TV with HDMI & AdapterĮstablishing the initial connection is remarkably straightforward and is just a matter of physically connecting the cables to one another from the Mac to the TV. Again, note that the latest MacBook Pro models have an HDMI port, so you wouldn’t need an adapter on one of those MacBook Pro models, you can just directly connect an HDMI cable between the Mac and the TV. 15 feet is usually adequate for most cases, but if you have a gigantic room you may want a longer cable.įor the purpose of this walkthrough we’ll focus on the newer Mac models with a built-in HDMI, Mini-DisplayPort, and/or Thunderbolt ports, this guide was crafted using a MacBook Air and MacBook Pro, but the same applies to newer Mac Mini and iMac models too. If you plan to control the TV using your Mac from a distance, spend a couple extra bucks on a longer HDMI cable. Also note that for 2010 and older Macs, the Mini-DVI to HDMI adapters do not carry audio at all, thus you will need a separate audio output option that we won’t cover here (external speakers, separate audio cable, etc). I’ve had the best experience with the Monoprice brand, but your mileage may vary. Generally, the adapters that cost a little bit more tend to be more reliable, so be sure to read the reviews and make sure that audio does indeed work for the adapter you are ordering. Note about HDMI adapters and audio support: there are many options available on Amazon and some are very cheap, many of which will not actually carry audio despite advertising that they do. HDTV with HDMI input, just about any modern HDTV.HDMI cable ($5-$20 depending on length).Mini DisplayPort/Thunderbolt to HDMI Adapter with Audio Support ($10-$15).Mac with Mini-DisplayPort, Mini-DVI*, HDMI, or Thunderbolt port.Virtually every semi-modern Mac will fit the bill, but you will need the following: Lets get started and cover the basic requirements first. Yes, the AirPlay feature can also export a screen to show up on a TV through an Apple TV box, but the HDMI method has several distinct advantages it’s cheaper, resource usage is considerably less, there are no slowdowns, the video quality does not depend on network latency, and it’s just generally much more versatile, making the only real downside to the HDMI approach being the physical cable connectivity. HDMI is really the best way to connect a MacBook Air, MacBook Pro, MacBook, iMac, or Mini to an HDTV screen, whatever your intended usage purpose is. The result will be the Mac exporting both video and audio signals to the TV. We’re going to focus on connecting any newer Mac to any fairly modern TV by way of a physical HDMI connection, thus, a few third party accessories will be necessary for the task. Ever wanted to connect a Mac to a TV screen? Maybe you want to use the TV as a giant external monitor, to play games on a big screen, or just for video playback and movie streaming? It’s actually quite easy to do, and we’ll cover the entire process from start to finish. |
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